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Tocris Bioscience™ PT-65
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Catalog No. 76515
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Catalog No. Quantity
76-515 5 mg
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Catalog No. 76-515 Supplier Tocris Bioscience™ Supplier No. 7651/5
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Description

Potent GSK3 Degrader (PROTAC™)

PT-65 is a potent GSK3 Degrader (PROTAC®) (DC50 = 28.3 nM and 34.2 nM against GSK3α and GSK3β, respectively, in SH-SY5Y cells). It suppresses Okadaic acid (Cat. No. 1136) -induced tau hyperphosphorylation and ameliorates learning and memory impairments in rat models of Alzheimer's disease.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material 3-Amino-6-(4-((4-(4-(1-(17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)-1 H-1,2,3-triazol-4-yl)butyl)piperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide
CAS 2721998-87-2
Quantity 5 mg
Target Active Degraders
Molecular Formula C51H63N13O12S
Purity 0.98
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