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Invitrogen™ PTCH Polyclonal Antibody
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Catalog No. PA14134
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100 μg
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Catalog No. Quantity
PA14134 100 μg
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Catalog No. PA14134 Supplier Invitrogen™ Supplier No. PA14134
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Description

Rabbit Polyclonal Antibody

PA1-4134 detects Patched (PTCH) in human samples. PA1-4134 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~158 kDa protein representing PTCH in fetal brain lysate. The PA1-4134 immunogen is a synthetic peptide corresponding to residues K(269) K I N Y Q V D S W E(279) of mouse PTCH. This sequence is 100% conserved in human, rat, and chicken PTCH, and is expected to cross react with these samples.

This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PTCH
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Ptch1
Gene Accession No. Q13635, Q61115, Q90693
Gene Alias A230106A15Rik; BCNS; etID309849.2; FLJ26746; FLJ42602; HGNC:9585; HPE7; lep; leprechaun; mes; mesenchymal dysplasia; NBCCS; OTTHUMP00000021709; OTTHUMP00000021710; patched; Patched 1; patched 2; patched homolog 1; patched homolog 2; patched protein; patched1; patched-2 protein; patched-like protein; protein patched homolog 1; Ptc; ptc1; ptc-1; ptc2; Ptch; PTCH protein +12b; PTCH protein +4'; PTCH protein -10; PTCH protein -3; PTCH protein -3,4,5; PTCH1; Ptch1 protein +12b; PTCH11; Ptch2; RP11-435O5.3
Gene Symbols Ptch1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues K(269) K I N Y Q V D S W E(279) of mouse PTCH.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19206, 395806, 5727, 89830
Target Species Human, Mouse, Rat, Chicken
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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