Invitrogen™ PTCH Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA518544

Catalog No. PIPA518544

Description

This antibody is predicted to react with bovine, canine and porcine based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.

This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

Specifications

• Antigen: PTCH
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ptch1
• Gene Alias: A230106A15Rik; BCNS; etID309849.2; FLJ26746; FLJ42602; HGNC:9585; HPE7; lep; leprechaun; mes; mesenchymal dysplasia; NBCCS; OTTHUMP00000021709; OTTHUMP00000021710; patched; Patched 1; patched 2; patched homolog 1; patched homolog 2; patched protein; patched1; patched-2 protein; patched-like protein; protein patched homolog 1; Ptc; ptc1; ptc-1; ptc2; Ptch; PTCH protein +12b; PTCH protein +4'; PTCH protein -10; PTCH protein -3; PTCH protein -3,4,5; PTCH1; Ptch1 protein +12b; PTCH11; Ptch2; RP11-435O5.3
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 19206, 5727
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q13635, Q61115
• Gene Symbols: Ptch1
• Immunogen: Synthetic peptide sequence (HPESRHHPPSNPRQQ) corresponding to the internal amino acids of PTCH (aa 1271-1285).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG