Invitrogen™ PTGDS Monoclonal Antibody (07)

Catalog No.	Quantity
PIMA530796	100 μL

Catalog No. PIMA530796 Supplier Invitrogen™ Supplier No. MA530796

Description

Mouse Monoclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Human PTGDS/L-PGDS.

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. PTGDS has also been implicated in the development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer's disease.

Specifications

• Antigen: PTGDS
• Applications: ELISA
• Classification: Monoclonal
• Clone: 07
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative
• Gene: PTGDS
• Gene Accession No.: P41222
• Gene Alias: 21kDa; Beta-trace protein; cerebrin-28; Glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin D synthase; lipocalin-type prostaglandin-D synthase; LPGDS; L-PGDS; PDS; PGD2; PGD2 synthase; PGDS; PGDS2; PH2DISO; Prostaglandin D synthase; prostaglandin D2 synthase; prostaglandin D2 synthase (21 kDa, brain); prostaglandin D2 synthase (brain); prostaglandin D2 synthase 21kDa (brain); prostaglandin-D2 synthase; Prostaglandin-H2 D-isomerase; Ptgds; Ptgs3; testis tissue sperm-binding protein Li 63n
• Gene Symbols: PTGDS
• Host Species: Mouse
• Immunogen: Recombinant Human PTGDS/L-PGDS Protein (Met1-Gln190).
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5730
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1