Invitrogen™ PTGDS Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA595977

Catalog No. PIPA595977

Description

Immunogen sequence: APEAQVSVQP NFQQDKFLGR WFSAGLASNS SWLREKKAAL SMCKSVVAPA TDGGLNLTST FLRKNQCETR TMLLQPAGSL GSYSYRSPHW GSTYSVSVVE TDYDQYALLY SQGSKGPGED FRMATLYSRT QTPRAELKEK FTAFCKAQGF TEDTIVFLPQ TDKCMTEQ; Positive Samples: Mouse heart; Cellular Location: Cytoplasm, Golgi apparatus, Nucleus membrane, Rough endoplasmic reticulum, perinuclear region.

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. PTGDS has also been implicated in the development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer's disease.

Specifications

• Antigen: PTGDS
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PTGDS
• Gene Alias: 21kDa; Beta-trace protein; cerebrin-28; Glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin D synthase; lipocalin-type prostaglandin-D synthase; LPGDS; L-PGDS; PDS; PGD2; PGD2 synthase; PGDS; PGDS2; PH2DISO; Prostaglandin D synthase; prostaglandin D2 synthase; prostaglandin D2 synthase (21 kDa, brain); prostaglandin D2 synthase (brain); prostaglandin D2 synthase 21kDa (brain); prostaglandin-D2 synthase; Prostaglandin-H2 D-isomerase; Ptgds; Ptgs3; testis tissue sperm-binding protein Li 63n
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19215, 25526, 5730
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.19 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O09114, P22057, P41222
• Gene Symbols: PTGDS
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 23-190 of human PTGDS (NP_0009453).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG