Invitrogen™ PTGDS Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA146022

Catalog No. PA146022

Description

This antibody has an 87% sequence homology with ovine and a 82% homology with rabbit. Suggested positive control: antigen standard for PTGDS (transient overexpression lysate), human brain protein.

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. PTGDS has also been implicated in the development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer's disease.

Specifications

• Antigen: PTGDS
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PTGDS
• Gene Alias: 21kDa; Beta-trace protein; cerebrin-28; Glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin D synthase; lipocalin-type prostaglandin-D synthase; LPGDS; L-PGDS; PDS; PGD2; PGD2 synthase; PGDS; PGDS2; PH2DISO; Prostaglandin D synthase; prostaglandin D2 synthase; prostaglandin D2 synthase (21 kDa, brain); prostaglandin D2 synthase (brain); prostaglandin D2 synthase 21kDa (brain); prostaglandin-D2 synthase; Prostaglandin-H2 D-isomerase; Ptgds; Ptgs3; testis tissue sperm-binding protein Li 63n
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100067921, 19215, 25526, 286858, 397456, 493852, 5730
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 30% glycerol and 0.1% sodium azide
• Gene Accession No.: O02853, O09114, O97921, P22057, P41222, Q29095, Q29487
• Gene Symbols: PTGDS
• Immunogen: A synthetic peptide made to a region within residues 25-100 of the human PTGDS protein.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Rabbit, Monkey, Bovine, Pig, Feline, Horse, Fish
• Product Type: Antibody
• Isotype: IgG