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PTGER2 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA132674
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25 μg
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PIPA132674 25 μg
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Catalog No. PIPA132674 Supplier Thermo Scientific Supplier No. PA132674

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Rabbit Polyclonal Antibody

PA1-32674 detects PTGER2 from human samples.

Prostaglandins are produced by the metabolism of arachidonic acid. Prostaglandin E2 is one of the five physiologically significant prostanoids known. Its wide spectrum of physiologic and pharmacologic effects in various tissues is mediated through binding to the Prostaglandin E2 receptors (EP1, EP2, EP3 & EP4). These include effects on the immune, endocrine, cardiovascular, renal and reproductive systems as well as smooth muscle. It is also one of the most abundant of the prostanoid family in the brain where it plays an important role in many neural functions, particularly in newborn babies, and as a mediator of inflammation. PGE-2 signals through a family of G-protein coupled receptors known as EP receptors. There are 4 subtypes of EP receptors, known as EP1, EP2, EP3 and EP4. EP2 receptors are 358 amino acid proteins with a short third intracellular loop. EP2 receptors stimulate adenylyl cyclase by their coupling to Gs and do not undergo PGE-2-induced internalization. The EP2 receptors is involved with the contration and relaxation of smooth muscle tissue. These receptors are mainly localized in lung and placental tissues and in smooth muscle.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PTGER2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene PTGER2
Gene Accession No. P43116
Gene Alias EP2; EP2 receptor; PGE receptor EP2 subtype; PGE receptor, EP2 subtype; PGE2 receptor EP2 subtype; Pge2-r ep2; prostaglandin E receptor 2; prostaglandin E receptor 2 (EP2 subtype); prostaglandin E receptor 2 (subtype EP2); prostaglandin E receptor 2 (subtype EP2), 53kD; prostaglandin E receptor 2 (subtype EP2), 53kDa; prostaglandin E receptor EP2 subtype; prostaglandin E receptor subtype EP2; prostaglandin E2 receptor EP2; prostaglandin E2 receptor EP2 subtype; prostaglandin E2 receptor EP2 subtype pseudogene; prostaglandin E2 receptor type 2; prostanoid EP2 receptor; Ptger2; Ptgerep2; Ptger-ep2
Gene Symbols PTGER2
Host Species Rabbit
Immunogen Synthetic 18 amino acid peptide from N-terminal extracellular domain of human Prostaglandin E Receptor EP2
Purification Method Antigen affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5732
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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