Invitrogen™ PTGER3 Polyclonal Antibody

Catalog No.	Quantity
PIPA5102057	100 μL

Catalog No. PIPA5102057 Supplier Invitrogen™ Supplier No. PA5102057

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PTGER3.

CD172a, also known as signal-regulatory protein alpha, is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and haematopoietic stem cells. CD172a acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways. Ligand binding of CD172a to integrin-associated protein CD47, results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of CD172a, mediating the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2. These then act as regulators of cellular function, through dephosphorylation of specific substrates. Ligation of CD172a with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs.

Specifications

• Antigen: PTGER3
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: PTGER3
• Gene Accession No.: P43115
• Gene Alias: EP3; Ep3 receptor; EP3A receptor; EP3B receptor; EP3C receptor; EP3D receptor; EP3e; EP3-I; EP3-II; EP3-III; EP3-IV; EP3-VI; MGC141828; MGC141829; MGC27302; PGE receptor EP3 subtype; PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; PGE2-R; Pgerep3; pr; prostaglandin E receotor EP3 subtype 3 isoform; prostaglandin E receptor 3; prostaglandin E receptor 3 (subtype EP3); prostaglandin E receptor EP3 subtype; prostaglandin E2 receptor EP3 subtype; prostaglandin receptor (PGE-2); prostanoid EP3 receptor; PTGER3; Ptgerep3; Rep3; rEP3a; rEP3b
• Gene Symbols: PTGER3
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human PTGER3(Accession P43115), corresponding to amino acid residues L353-R390.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5733
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG