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Invitrogen™ PTGER3 Polyclonal Antibody
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Catalog No. PIPA534120
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50 μg
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PIPA534120 50 μg
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Catalog No. PIPA534120 Supplier Invitrogen™ Supplier No. PA534120
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Description

Rabbit Polyclonal Antibody

Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Bovine, Horse, Pig (100%) Gorilla, Rat, Elephant, Bat, Rabbit (94%).

CD172a, also known as signal-regulatory protein alpha, is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and haematopoietic stem cells. CD172a acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways. Ligand binding of CD172a to integrin-associated protein CD47, results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of CD172a, mediating the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2. These then act as regulators of cellular function, through dephosphorylation of specific substrates. Ligation of CD172a with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PTGER3
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.91 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene PTGER3
Gene Accession No. P34979, P43115, P50131
Gene Alias EP3; Ep3 receptor; EP3A receptor; EP3B receptor; EP3C receptor; EP3D receptor; EP3e; EP3-I; EP3-II; EP3-III; EP3-IV; EP3-VI; MGC141828; MGC141829; MGC27302; PGE receptor EP3 subtype; PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; PGE2-R; Pgerep3; pr; prostaglandin E receotor EP3 subtype 3 isoform; prostaglandin E receptor 3; prostaglandin E receptor 3 (subtype EP3); prostaglandin E receptor EP3 subtype; prostaglandin E2 receptor EP3 subtype; prostaglandin receptor (PGE-2); prostanoid EP3 receptor; PTGER3; Ptgerep3; Rep3; rEP3a; rEP3b
Gene Symbols PTGER3
Host Species Rabbit
Immunogen Synthetic 16 amino acid peptide from 1st cytoplasmic domain of human PTGER3 / EP3.
Purification Method Antigen Affinity Chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100053557, 282330, 396811, 5733
Target Species Human, Monkey, Bovine, Pig, Horse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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