Invitrogen™ PTGES2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120215

Catalog No. PIPA5120215

Description

Positive test controls include: 293T, HeLa, BT-474, HL-60, Rat brain. The target is usually found in the following locations: Cytoplasm, Golgi apparatus membrane, Single-pass membrane protein, perinuclear region. Immunogen sequence: ERSAAQLSLS SRLQLTLYQY KTCPFCSKVR AFLDFHALPY QVVEVNPVRR AEIKFSSYRK VPILVAQEGE SSQQLNDSSV IISALKTYLV SGQPLEEIIT YYPAMKAVNE QGKEVTEFGN KYWLMLNEKE AQQVYGGKEA RTEEMKWRQW ADDWLVHLIS PNVYRTPTEA LASFDYIVRE GKFGAVEGAV AKYMGAAAMY LISKRLKSRH RLQDNVREDL YEAADKWVAA VGKDRPFMGG QKPNLADLAV YGVLRVMEGL DAFDDLMQHT HIQPWYLRVE RAITEASPAH.

The PTGES2 gene encodes for the enzyme prostaglandin E synthase 2 (PTGES2), which is crucial for the biosynthesis of prostaglandin E2 (PGE2) from arachidonic acid. This enzyme operates downstream of the cyclooxygenase (COX) pathway, particularly interacting with COX-1 and COX-2 enzymes. PTGES2 is involved in various physiological and pathological processes by generating PGE2, which functions in inflammation, fever generation, and pain. Notably, PTGES2 is a membrane-associated protein and is distinct in its role compared to other prostaglandin synthases due to its specific functional and regulatory properties. Its activity is essential in fine-tuning the levels of PGE2 in tissues, impacting numerous signaling cascades, including those involved in immune responses and vascular functions.

Specifications

• Antigen: PTGES2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ptges2
• Gene Alias: 0610038H10Rik; C79137; C9orf15; FLJ14038; gamma-interferon-activated transcriptional element-binding factor 1; GATE-binding factor 1; Gbf1; GBF-1; membrane-associated prostaglandin E synthase 2; membrane-associated prostaglandin E synthase-2; MGC11289; Microsomal prostaglandin E synthase 2; microsomal prostaglandin E synthase-2; mPGE synthase-2; Mpges2; mPGES-2; PGES2; Prostaglandin E synthase 2; Prostaglandin E synthase 2 truncated form; Prostaglandin-H(2) E-isomerase; PTGES2; RP11-395P17.2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 311865, 80142, 96979
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 2.72 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8BWM0, Q9H7Z7
• Gene Symbols: Ptges2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 88-377 of human PTGES2 (NP_079348.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov