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Invitrogen™ PTGR2 Polyclonal Antibody
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Catalog No. PIPA5101972
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PIPA5101972 100 μL
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Catalog No. PIPA5101972 Supplier Invitrogen™ Supplier No. PA5101972
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ZADH1.

ZADH1 (zinc binding alcohol dehydrogenase, domain containing 1), also known as PTGR2 (prostaglandin reductase 2), PGR2 or 15-oxoprostaglandin 13-reductase, is a 351 amino acid cytoplasmic protein that belongs to the NADP-dependent oxidoreductase L4BD family. Functioning as s a 15-oxoprostaglandin 13-reductase, ZADH1 catalyzes the conversion of 15-keto-prostaglandin E2 to 15-keto-13, 14-dihydro-prostaglandin E2 in a NADPH-dependent manner. ZADH1 overexpression has been found to repress PPAR gamma transcriptional activity and adipocyte differentiation. Widely expressed, ZADH1 is found at highest levels in heart, kidney, liver, pancreas and prostate, with moderate levels found in brain, small intestine, lung, testis and skeletal muscle. ZADH1 exists as a monomer, utilizes NADPH as a cofactor, and undergoes alternative splicing to produce two isoforms that are encoded by a gene located on human chromosome 14q24.3.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PTGR2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene PTGR2
Gene Accession No. Q5BK81, Q8N8N7
Gene Alias 15-oxoprostaglandin 13-reductase; 15-oxoprostaglandin 13-reductase {ECO:0000250; 15-oxoprostaglandin-delta13-reductase; 1810016I24Rik; 9130222H03Rik; 9630002F03Rik; AI838763; B830026H24Rik; epididymis secretory protein Li 298; HEL-S-298; PGR2; PGR-2; PRG2; PRG-2; PRG-2 {ECO:0000250; prostaglandin reductase 2; prostaglandin reductase 2 {ECO:0000250; PTGR2; ptgr2 {ECO:0000250; UniProtKB:Q8VDQ1}; ZADH1; zinc binding alcohol dehydrogenase, domain containing 1; zinc-binding alcohol dehydrogenase domain-containing protein 1
Gene Symbols PTGR2
Host Species Rabbit
Immunogen A synthesized peptide derived from human PTGR2(Accession Q8N8N7), corresponding to amino acid residues I186-I236.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 145482, 299194
Target Species Human, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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