Invitrogen™ PTGR2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA537089

Catalog No. PIPA537089

Description

This antibody detects endogenous protein at a molecular weight of 38 kDa. Purity is >95% by SDS-PAGE.

ZADH1 (zinc binding alcohol dehydrogenase, domain containing 1), also known as PTGR2 (prostaglandin reductase 2), PGR2 or 15-oxoprostaglandin 13-reductase, is a 351 amino acid cytoplasmic protein that belongs to the NADP-dependent oxidoreductase L4BD family. Functioning as s a 15-oxoprostaglandin 13-reductase, ZADH1 catalyzes the conversion of 15-keto-prostaglandin E2 to 15-keto-13, 14-dihydro-prostaglandin E2 in a NADPH-dependent manner. ZADH1 overexpression has been found to repress PPAR gamma transcriptional activity and adipocyte differentiation. Widely expressed, ZADH1 is found at highest levels in heart, kidney, liver, pancreas and prostate, with moderate levels found in brain, small intestine, lung, testis and skeletal muscle. ZADH1 exists as a monomer, utilizes NADPH as a cofactor, and undergoes alternative splicing to produce two isoforms that are encoded by a gene located on human chromosome 14q24.3.

Specifications

• Antigen: PTGR2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PTGR2
• Gene Alias: 15-oxoprostaglandin 13-reductase; 15-oxoprostaglandin 13-reductase {ECO:0000250; 15-oxoprostaglandin-delta13-reductase; 1810016I24Rik; 9130222H03Rik; 9630002F03Rik; AI838763; B830026H24Rik; epididymis secretory protein Li 298; HEL-S-298; PGR2; PGR-2; PRG2; PRG-2; PRG-2 {ECO:0000250; prostaglandin reductase 2; prostaglandin reductase 2 {ECO:0000250; PTGR2; ptgr2 {ECO:0000250; UniProtKB:Q8VDQ1}; ZADH1; zinc binding alcohol dehydrogenase, domain containing 1; zinc-binding alcohol dehydrogenase domain-containing protein 1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 145482, 299194, 77219
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q5BK81, Q8N8N7, Q8VDQ1
• Gene Symbols: PTGR2
• Immunogen: Synthetic peptide corresponding to amino acids 228-273 of human ZADH1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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