Invitrogen™ PTMA Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5142436

Catalog No. PIPA5142436

Description

Additional Information: This antibody is expected to recognize both reported isoforms (NP_001092755.1; NP_002814.3). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:1,000.

The thymus gland produces several hormones or hormone-like substances which are derived from a polypeptide precursor containing (in the rat) 113 amino acids and known as prothymosin-alpha. A peptide containing 28 amino acid residues, named thymosin-alpha-1, was originally isolated from calf thymosin fraction 5 and shown to restore various aspects of immune function in several in vitro and invivo test systems. Thymosin-alpha-1 was subsequently isolated from a similar fraction from human thymosin and reported to have the same amino acid sequence as bovine thymosin-alpha-1. In 2003, Jiang et al. identified a pathway that regulates mitochondria-initiated caspase activity. In this pathway, putative human HLA class II-associated protein (PHAP) promoted caspase-9 activation after apoptosome formation, whereas prothymosin-alpha-1 negatively regulated caspase-9 activation by inhibiting apoptosome formation.

Specifications

• Antigen: PTMA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PTMA
• Gene Alias: alpha-prothymosin; gene sequence 28; prothymosin alpha; prothymosin alpha protein; Prothymosin alpha, N-terminally processed; prothymosin, alpha; prothymosin-alpha; PTMA; Thym; thymosin; Thymosin alpha; Thymosin alpha-1; TMSA; TMSB4; TMSB4X
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 5757
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P06454
• Gene Symbols: PTMA
• Immunogen: Peptide with sequence C-DVDTKKQKTDEDD.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG