PTMA Polyclonal Antibody, Invitrogen™

Chicken Polyclonal Antibody

Supplier:  Thermo Scientific PA19532

Catalog No. 01-674-415

Description

PA1-9532 detects Thymosin in human, mouse, pig and rat samples. PA1-9532 has been successfully used in ELISA procedures. PA1-9532 immunogen is a synthetic peptide based on human thymosin protein.

The thymus gland produces several hormones or hormone-like substances which are derived from a polypeptide precursor containing (in the rat) 113 amino acids and known as prothymosin-alpha. A peptide containing 28 amino acid residues, named thymosin-alpha-1, was originally isolated from calf thymosin fraction 5 and shown to restore various aspects of immune function in several in vitro and invivo test systems. Thymosin-alpha-1 was subsequently isolated from a similar fraction from human thymosin and reported to have the same amino acid sequence as bovine thymosin-alpha-1. In 2003, Jiang et al. identified a pathway that regulates mitochondria-initiated caspase activity. In this pathway, putative human HLA class II-associated protein (PHAP) promoted caspase-9 activation after apoptosome formation, whereas prothymosin-alpha-1 negatively regulated caspase-9 activation by inhibiting apoptosome formation.

Specifications

• Antigen: PTMA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PTMA
• Gene Alias: alpha-prothymosin; gene sequence 28; prothymosin alpha; prothymosin alpha protein; Prothymosin alpha, N-terminally processed; prothymosin, alpha; prothymosin-alpha; PTMA; Thym; thymosin; Thymosin alpha; Thymosin alpha-1; TMSA; TMSB4; TMSB4X
• Host Species: Chicken
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100294684, 19231, 29222, 5757
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P06302, P06454, P26350
• Gene Symbols: PTMA
• Immunogen: Synthetic peptide based on human thymosin protein.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Pig, Rat
• Product Type: Antibody
• Isotype: IgY

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov