PTP4A1/PRL1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-7222	Proteintech Group Inc 115081AP150UL	150 μL

Description

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells. PRL phosphatases increase cell proliferation by stimulating progression from G1 into S phase. PRL-1 function is regulated in a cell cycle-dependent manner and implicate PRL-1 in regulating progression through mitosis, possibly by modulating spindle dynamics.

Specifications

• Antigen: PTP4A1/PRL1
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q63739, Q78EG7, Q93096
• Gene ID (Entrez): 19243, 29463, 7803
• Immunogen: PTP4A1/PRL1 Fusion Protein Ag2067
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: PTP4A1

• Concentration: 0.23 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: HH72, PRL 1, PRL1, PTP(CAAX1), PTP(CAAXI), PTP4A1, PTPCAAX1
• Gene Symbols: PTP4A1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody