PTPH1 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-8887	100 μL

Catalog No. 50-198-8887 Supplier Bioss Supplier No. BS9187R

Description

Rabbit Polyclonal Antibody

Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation - it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.

Specifications

• Antigen: PTPH1
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: PTPN3
• Gene Accession No.: P26045
• Gene Alias: 9530011I20Rik; cytoskeletal-associated protein tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 3; Protein-tyrosine phosphatase H1; PTPCL; PTPH1; PTP-H1; PTPN3; Tyrosine-protein phosphatase non-receptor type 3
• Gene Symbols: PTPN3
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human PTPH1/PTPN3.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5774
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG