PTPN1 Mouse anti-Human, Clone:4F11B9, Abnova™

Mouse monoclonal antibody raised against recombinant human PTPN1.

Supplier:  Abnova Corporation MAB16642

Catalog No. 89-333-134

Description

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq]

Specifications

• Antigen: PTPN1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:10000)
  Western Blot (1:500-1:2000)
  Flow Cytometry (1:200-1:400)
  The optimal working dilution should be determined by the end user.
• Gene: PTPN1
• Host Species: Mouse
• Quantity: 100 μg
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Flow Cytometry, Western Blot
• Clone: 4F11B9
• Description: protein tyrosine phosphatase, non-receptor type 1
• Formulation: In PBS (0.05% sodium azide)
• Gene Alias: PTP1B
• Immunogen: Recombinant protein corresponding to amino acid 40-246 of human PTPN1 from E. coli.
• Gene ID (Entrez): 5770
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid