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Invitrogen™ PTPN13 Polyclonal Antibody
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Catalog No. PIPA572906
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PIPA572906 50 μL
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Catalog No. PIPA572906 Supplier Invitrogen™ Supplier No. PA572906
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Description

Rabbit Polyclonal Antibody

PTPN13 Polyclonal Antibody for Western Blot, ICC/IF, IHC (F), IHC (P), IP

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PTPN13
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Whole serum with 0.05% sodium azide
Gene PTPN13
Gene Accession No. Q12923
Gene Alias AI324989; DKFZp686J1497; FAP-1; Fas-associated protein-tyrosine phosphatase 1; hPTP1E; hPTPE1; PNP1; protein Tyr phosphatase; protein tyrosine phosphatase DPZPTP; Protein tyrosine phosphatase PTP-BL; protein tyrosine phosphatase, non-receptor type 13; protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase); protein-tyrosine phosphatase 1E; Protein-tyrosine phosphatase PTPL1; protein-tyrosine phosphatase RIP; ptp; Ptp14; PTP1E; PTP36; PTP-BAS; PTP-BL; PTP-E1; PTPL1; PTPLE; PTPN13; Ptpri; RIP; tyrosine phosphatase; tyrosine-protein phosphatase non-receptor type 13
Gene Symbols PTPN13
Host Species Rabbit
Immunogen A recombinant protein corresponding to amino acids 1279 to 1883 of human FAP-1 protein.
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5783
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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WARNING: Cancer - www.P65Warnings.ca.gov
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