Invitrogen™ PTPN2 Polyclonal Antibody

Catalog No.	Quantity
PIPA578138	100 μL

Catalog No. PIPA578138 Supplier Invitrogen™ Supplier No. PA578138

Description

Rabbit Polyclonal Antibody

Positive Control: 293T, A431, HeLa, HepG2 Predicted Reactivity: Rat (94%), Chicken (81%), Bovine (93%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. This enzyme has two C-terminal end splice variants with distinctly different subcellular localizations. The shorter 45 kilodalton isoform is exclusively nuclear in resting cells, but redistrubutes to the cytosol upon stimulation with growth factors and cellular stress. The longer 48 kilodalton isoform is exclusively found in the endoplasmic reticulum 3 and seems to have distinctly different physiologic substrates from the smaller isoform. Although found in many cell types and tissues, TC-PTP is particularly prominent in hemopoietic cell types. Knockout mice lacking TC-PTP are born viable but die 3 to 5 weeks after birth of erythropoietic and lymphopoietic deficits 7, indicating a critical role for TC-PTP in bone marrow maturation. TC-PTP will dephosphorylate a wide range of phosphoproteins, such as p52 Shc 6 and receptors for EGF 1, Insulin 8 and growth hormone.

Specifications

• Antigen: PTPN2
• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1.18 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene: PTPN2
• Gene Accession No.: P17706, Q06180
• Gene Alias: AI325124; hypothetical protein LOC540888; MPTP; protein tyrosine phosphatase non-receptor type 2; protein tyrosine phosphatase, non-receptor type 2; protein-tyrosine phosphatase PTP-2; Protein-tyrosine phosphatase PTP-S; PTN2; PTPN 2; PTPN2; Ptpt; T cell protein-tyrosine phosphatase; TC PTP; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatase; TCELLPTP; TCPTP; TC-PTP; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 2
• Gene Symbols: PTPN2
• Host Species: Rabbit
• Immunogen: Recombinant protein encompassing a sequence within the center region of human TCPTP. The exact sequence is proprietary.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 19255, 5771
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG