Invitrogen™ PTPN2 Recombinant Rabbit Monoclonal Antibody (001)

Catalog No.	Quantity
PIMA531216	100 μL

Catalog No. PIMA531216 Supplier Invitrogen™ Supplier No. MA531216

Description

Rabbit Recombinant Monoclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. This antibody has specificity for Mouse PTPN2/TC-PTP.

T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. This enzyme has two C-terminal end splice variants with distinctly different subcellular localizations. The shorter 45 kilodalton isoform is exclusively nuclear in resting cells, but redistrubutes to the cytosol upon stimulation with growth factors and cellular stress. The longer 48 kilodalton isoform is exclusively found in the endoplasmic reticulum 3 and seems to have distinctly different physiologic substrates from the smaller isoform. Although found in many cell types and tissues, TC-PTP is particularly prominent in hemopoietic cell types. Knockout mice lacking TC-PTP are born viable but die 3 to 5 weeks after birth of erythropoietic and lymphopoietic deficits 7, indicating a critical role for TC-PTP in bone marrow maturation. TC-PTP will dephosphorylate a wide range of phosphoproteins, such as p52 Shc 6 and receptors for EGF 1, Insulin 8 and growth hormone.

Specifications

• Antigen: PTPN2
• Applications: ELISA
• Classification: Recombinant Monoclonal
• Clone: 001
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative
• Gene: PTPN2
• Gene Accession No.: Q06180
• Gene Alias: AI325124; hypothetical protein LOC540888; MPTP; protein tyrosine phosphatase non-receptor type 2; protein tyrosine phosphatase, non-receptor type 2; protein-tyrosine phosphatase PTP-2; Protein-tyrosine phosphatase PTP-S; PTN2; PTPN 2; PTPN2; Ptpt; T cell protein-tyrosine phosphatase; TC PTP; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatase; TCELLPTP; TCPTP; TC-PTP; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 2
• Gene Symbols: PTPN2
• Host Species: Rabbit
• Immunogen: Recombinant Mouse PTPN2/TC-PTP Protein (Ser2-Asn314).
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 19255
• Target Species: Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG