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PTPRC Rat anti-Human, Mouse, APC, Clone: RA3-6B2, Abnova™

Catalog No. 89934823 Shop All Abnova Corporation Products
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89-934-823 100 μg
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Catalog No. 89-934-823 Supplier Abnova Corporation Supplier No. MAB12228
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Description

Rat monoclonal antibody raised against PTPRC.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq]

Specifications

Antigen PTPRC
Applications Flow Cytometry
Classification Monoclonal
Clone RA3-6B2
Conjugate APC
Description Rat monoclonal antibody raised against Ptprc.
Dilution Flow Cytometry The optimal working dilution should be determined by the end user.
Formulation In PBS, pH7.2 (0.09% Sodium azide, may contain carrier protein/stabilizer).
Gene Alias B220/CD45R/Cd45/Ly-5/Lyt-4/T200/loc
Gene Symbols Ptprc
Host Species Rat
Immunogen Abelson murine leukemia virus-induced pre-B tumor cells.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19264
Target Species Human, Mouse
Content And Storage Store in the dark at 4°C. Avoid prolonged exposure to light. Do not freeze.
Form Liquid
Isotype IgG2a κ
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