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Invitrogen™ PTPRN2 Polyclonal Antibody
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Catalog No. PIPA590035
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PIPA590035 100 μL
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Catalog No. PIPA590035 Supplier Invitrogen™ Supplier No. PA590035
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AAPSSVPRGR QLPGRLGCLL EEGLCGASEA CVNDGVFGRC QKVPAMDFYR YEVSPVALQR LRVALQKLSG TGFTWQDDYT QYVMDQELAD LPKTYLRRPE ASSPARPSKH SVGSERRYSR EGGAALANAL RRHLPFLEAL SQAPASDVLA RTHTAQDRPP AEGDDRFSES ILTYVAHTSA LTYPPGSRTQ LREDLLPRTL GQLQPDELSP KVDSGVDRHH L; Positive Samples: SH-SY5Y, SGC-7901, Mouse pancreas, Rat pancreas; Cellular Location: Cytoplasmic vesicle, Single-pass type I membrane protein, secretory vesicle, secretory vesicle membrane, synaptic vesicle membrane.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PTPRN2
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 2.74 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene PTPRN2
Gene Accession No. P80560, Q63475, Q92932
Gene Alias 4930425H11Rik; EC 3.1.3.48; IA-2 beta; IA2beta; IA-2beta; IA-2beta60; IA-2beta64; IA-2beta71; IAR; IAR/receptor-like protein-tyrosine phosphatase; ICAAR; Islet cell autoantigen-related protein; KIAA0387; mKIAA0387; phogrin; Phol; protein tyrosine phosphatase receptor pi; protein tyrosine phosphatase receptor-type N polypeptide 2; protein tyrosine phosphatase, receptor type N2; protein tyrosine phosphatase, receptor type, N polypeptide 2; protein tyrosine phosphatase, receptor-type, N polypeptide 2; protein tyrosine phosphatase-NP; PTP IA-2beta; PTP NE-6; PTPNE6; PTP-NP; PTPRN2; PTPRP; Receptor-type tyrosine-protein phosphatase N2; R-PTP-N2; tyrosine phosphatase IA-2 beta
Gene Symbols PTPRN2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 22-242 of human PTPRN2 (NP_5708582).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19276, 29714, 5799
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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