Invitrogen™ PTPRS Polyclonal Antibody

Catalog No.	Quantity
PIPA547487	100 μg

Catalog No. PIPA547487 Supplier Invitrogen™ Supplier No. PA547487

Description

Goat Polyclonal Antibody

This antibody detects the endogenous cleaved extracellular domain of human PTP sigma /PTPRS in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human LAR, PTPR beta, PTPR gamma, PTPR mu, or PTPR kappa is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

PTPRS cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta.

Specifications

• Antigen: PTPRS
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5% trehalose and No Preservative
• Gene: Ptprs
• Gene Accession No.: Q13332
• Gene Alias: AL022616; Larptp2; LAR-PTP2; Leukocyte common antigen-related protein-tyrosine phosphatase 2; leukocyte common antigen-related proten-tyrosine phosphatase 2; protein tyrosine phosphatase PTPsigma; protein tyrosine phosphatase, receptor type S; protein tyrosine phosphatase, receptor type, D; protein tyrosine phosphatase, receptor type, S; PTP; PTP-NU3; PTPNU-3; Ptprd; Ptprs; PTPsigma; Ptpsigma.; Ptpt9; Receptor-type tyrosine-protein phosphatase S; Receptor-type tyrosine-protein phosphatase sigma; Rptpd; R-PTP-S; RPTPsigma; R-PTP-sigma; tissue-specific protein tyrosine phosphatase
• Gene Symbols: Ptprs
• Host Species: Goat
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human PTP sigma/PTPRS Glu30-Gly1260.
• Purification Method: Antigen Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5802
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG