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Invitrogen™ PTRF Polyclonal Antibody
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Catalog No. PIPA584948
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PIPA584948 100 μL
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Catalog No. PIPA584948 Supplier Invitrogen™ Supplier No. PA584948
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VSVNVKTVRG SLERQAGQIK KLEVNEAELL RRRNFKVMIY QDEVKLPAKL SISKSLKESE ALPEKEGEEL GEGERPEEDA AALELSSD Highest antigen sequence indentity to the following orthologs: Rat - 97%, Mouse - 94%.

The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts. PTRF also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins, translocating from caveolae to the cytoplasm after insulin stimulation. PTRF is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PTRF
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CAVIN1
Gene Accession No. Q6NZI2
Gene Alias 2310075E07Rik; AW546441; caveolae associated protein 1; caveolae-associated protein 1; CAVIN; CAVIN1; cavin-1; Cav-p60; CGL4; FKSG13; FLJ90031; Polymerase I and transcript release factor; PTRF; ptrf {ECO:0000312; RGD:1307685}; RNA polymerase I and transcript release factor; TTF-I interacting peptide 12
Gene Symbols CAVIN1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CAVIN1. Recombinant protein control fragment (Product #RP-107984).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 284119
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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