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Invitrogen™ PTRF Polyclonal Antibody
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Catalog No. PIPA5118795
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100 μL
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PIPA5118795 100 μL
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Catalog No. PIPA5118795 Supplier Invitrogen™ Supplier No. PA5118795
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PTRF.

The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts. PTRF also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins, translocating from caveolae to the cytoplasm after insulin stimulation. PTRF is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PTRF
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CAVIN1
Gene Accession No. O54724, P85125, Q6NZI2
Gene Alias 2310075E07Rik; AW546441; caveolae associated protein 1; caveolae-associated protein 1; CAVIN; CAVIN1; cavin-1; Cav-p60; CGL4; FKSG13; FLJ90031; Polymerase I and transcript release factor; PTRF; ptrf {ECO:0000312; RGD:1307685}; RNA polymerase I and transcript release factor; TTF-I interacting peptide 12
Gene Symbols CAVIN1
Host Species Rabbit
Immunogen A synthesized peptide derived from human CAVIN1(Accession Q6NZI2), corresponding to amino acid residues R130-E180.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19285, 284119, 287710
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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