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Invitrogen™ PTX3 Monoclonal Antibody (2C3)
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Catalog No. PIMA533376
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100 μg
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PIMA533376 100 μg
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Catalog No. PIMA533376 Supplier Invitrogen™ Supplier No. MA533376
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Description

Mouse Monoclonal Antibody

Product is supplied at 1 mL (100 μL/mL). Application Notes: Western blot- A non-reduced sample treatment and SDS-Page was used. The band size is 400 kDa. Flow cytometry - This antibody stains the intra and extracellular domain of Pentraxin 3. For intracellular staining cells were permeabilized with buffer containing triton. Transfected cells were used as a positive control.

Pentraxins are a protein superfamily that is characterized by a cyclic multimeric structure. Ptx3, also known as tumor necrosis factor-stimulated gene sequence-14 (TSG14), is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents. Ptx3 belongs to the family of long pentraxins, which have C-terminal pentraxin domains and novel amino-terminal domains. Ptx3 binds selected pathogens, including Aspergillus fumigatus, Pseudomonas aeruginosa and Salmonella typhimurium. It is synthesized in IgA glomerulonephritis and activates mesangial cells. Secretion of Ptx3 in adipose cells can be induced by TNF. Ptx3 is also involved in amplification of inflammatory reactions and regulation of innate immunity. The human PTX3 gene maps to chromosome 3q25.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PTX3
Applications ELISA, Flow Cytometry, Functional Assay, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 2C3
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA and no preservative
Gene PTX3
Gene Accession No. P48759
Gene Alias AI607804; long pentraxin 3; pentaxin related; pentaxin-related protein PTX3; pentraxin 3; pentraxin 3, long; pentraxin related; pentraxin related gene; pentraxin-related protein PTX3; Ptx3; TNF alpha-induced protein 5; TNFAIP5; Tsg14; TSG-14; Tumor necrosis factor alpha-induced protein 5; tumor necrosis factor-inducible gene 14 protein; tumor necrosis factor-inducible protein TSG-14
Gene Symbols PTX3
Host Species Mouse
Immunogen Recombinant mouse PTX3.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19288
Target Species Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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