PU.1/Spi-1, Mouse anti-Human, Janelia Fluor 549, Clone: PU1/2146, Novus Biologicals™
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP275766JF549
DescriptionPU.1/Spi-1 Monoclonal antibody specifically detects PU.1/Spi-1 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry (Paraffin).
|Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin|
|50mM Sodium Borate with 0.05% Sodium Azide|
|Recombinant fragment (around aa 16-170) of human PU.1 protein (Exact sequence is proprietary)|
|Protein A or G purified|
|Store at 4°C in the dark.|
|PU.1 is a member of the ETS family of transcription factors and is important for normal B-cell development. It is expressed in the myeloid lineage and in immature as well as mature B-lymphocytes, with the exception of plasma cells. PU.1 is expressed in germinal center B-cells and mantle B-cells. Various lymphomas are also positive for this marker. It is essential during early B-cell differentiation. The absence of PU.1 results in total block of B-cell development at the pre-pro stage. PU.1 plays a key role in normal myeloid differentiation, and regulates the expression of immunoglobulin and other genes that are important for B-cell development.|
|Western Blot,Flow Cytometry,Immunohistochemistry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Paraffin)|
|Janelia Fluor 549|
|hematopoietic transcription factor PU.1, OF, PU.1, SFPI131 kDa transforming protein, SPI-1, SPI-1 proto-oncogene, SPI-A, spleen focus forming virus (SFFV) proviral integration oncogene spi1,31 kDa-transforming protein, transcription factor PU.1|
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