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Invitrogen™ PUM1 Polyclonal Antibody
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Catalog No. PIPA589209
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100 μL
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PIPA589209 100 μL
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Catalog No. PIPA589209 Supplier Invitrogen™ Supplier No. PA589209
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MSVACVLKRK AVLWQDSFSP HLKHHPQEPA NPNMPVVLTS GTGSQAQPQP AANQALAAGT HSSPVPGSIG VAGRSQDDAM VDYFFQRQHG EQLGGGGSGG GGYNNSKHRW PTGDNIHAEH QVRSMDELNH; Positive Samples: HepG2, SH-SY5Y, Mouse liver; Cellular Location: Cytoplasm, Cytoplasmic granule, P-body.

PUM1 (pumilio homolog 1) is a sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. It is a member of the PUF family comprised of evolutionarily conserved RNA-binding proteins. PUM1 binds to an RNA consensus sequence, the Pumilio Response Element (PRE), and 5'-UGUANAUA-3' that is related to the Nanos Response Element (NRE). PUM1 mediates post-transcriptonal repression of transcripts via different mechanisms - acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Mutations to the gene can result in spinocerebellar ataxia 47.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PUM1
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.88 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene PUM1
Gene Accession No. Q14671, Q80U78
Gene Alias AA517475; HsPUM; KIAA0099; mKIAA0099; PUM1; PUMH; PUMH1; pumilio 1; pumilio homolog 1; pumilio RNA binding family member 1; pumilio RNA-binding family member 1; pumilio-1; PUML1; Pumm
Gene Symbols PUM1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human Pumilio 1 (NP_0554911).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 80912, 9698
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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