Invitrogen™ PUMA alpha Recombinant Rabbit Monoclonal Antibody (9C5W5)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA535398

Catalog No. PIMA535398

Description

Immunogen sequence: AEQHLESPVP SAPGALAGGP TQAAPGVRGE EEQWAREIGA QLRRMADDLN AQYERRRQEE QQRHRPSPWR VLYNLIMGLL PLPRGHRAPE MEPN.

PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.

Specifications

• Antigen: PUMA alpha
• Classification: Recombinant Monoclonal
• Concentration: 0.57 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q80ZG6, Q99ML1, Q9BXH1
• Gene Symbols: BBC3
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-193 of human PUMA (NP_055232.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 9C5W5
• Conjugate: Unconjugated
• Gene: BBC3
• Gene Alias: BBC3; BCL2 binding component 3; Bcl-2 binding component 3; bcl-2-binding component 3; Bcl-2-binding component 3, isoforms 1/2; Bcl-2-binding component 3, isoforms 3/4; BH3-only; FLJ42994; JFY1; JFY-1; p53 up-regulated modulator of apoptosis; PUMA; PUMA/JFY1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 170770, 27113, 317673
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid