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Invitrogen™ PUMA alpha Polyclonal Antibody
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Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA511397

Catalog No. PIPA511397


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Description

Description

This antibody is predicted to react with mouse and rat based on sequence homology.

PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PUMA alpha
Polyclonal
Unconjugated
BBC3
BBC3; BCL2 binding component 3; Bcl-2 binding component 3; bcl-2-binding component 3; Bcl-2-binding component 3, isoforms 1/2; Bcl-2-binding component 3, isoforms 3/4; BH3-only; FLJ42994; JFY1; JFY-1; p53 up-regulated modulator of apoptosis; PUMA; PUMA/JFY1
Rabbit
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
27113
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
1.5 mg/mL
PBS with 0.09% sodium azide; pH 7.4
Q9BXH1
BBC3
KLH conjugated synthetic peptide between 119-154 amino acids from human Puma BH3 Domain.
400 μL
Primary
Human
Antibody
IgG
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