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Invitrogen™ PUMA alpha Polyclonal Antibody

Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA511397
Description
This antibody is predicted to react with mouse and rat based on sequence homology.
PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
Specifications
PUMA alpha | |
Polyclonal | |
Unconjugated | |
BBC3 | |
BBC3; BCL2 binding component 3; Bcl-2 binding component 3; bcl-2-binding component 3; Bcl-2-binding component 3, isoforms 1/2; Bcl-2-binding component 3, isoforms 3/4; BH3-only; FLJ42994; JFY1; JFY-1; p53 up-regulated modulator of apoptosis; PUMA; PUMA/JFY1 | |
Rabbit | |
Ammonium sulfate precipitation, Size-exclusion - Dialysis | |
RUO | |
27113 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
1.5 mg/mL | |
PBS with 0.09% sodium azide; pH 7.4 | |
Q9BXH1 | |
BBC3 | |
KLH conjugated synthetic peptide between 119-154 amino acids from human Puma BH3 Domain. | |
400 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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