Pumilio 1 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-1178	100 μL

Catalog No. 50-198-1178 Supplier Bioss Supplier No. BS11218R

Description

Rabbit Polyclonal Antibody

PUM1 (pumilio homolog 1) is a sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3′-UTR of mRNA targets. It is a member of the PUF family comprised of evolutionarily conserved RNA-binding proteins. PUM1 binds to an RNA consensus sequence, the Pumilio Response Element (PRE), and 5′-UGUANAUA-3′ that is related to the Nanos Response Element (NRE). PUM1 mediates post-transcriptonal repression of transcripts via different mechanisms - acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Mutations to the gene can result in spinocerebellar ataxia 47.

Specifications

• Antigen: Pumilio 1
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: PUM1
• Gene Accession No.: Q14671
• Gene Alias: AA517475; HsPUM; Kiaa0099; mKIAA0099; PUM1; PUMH; PUMH1; pumilio 1; Pumilio homolog 1; pumilio RNA binding family member 1; pumilio RNA-binding family member 1; pumilio-1; PUML1; Pumm
• Gene Symbols: PUM1
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human Pumilio 1.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 9698
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG