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Purmorphamine, Tocris Bioscience™
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Quantity:
10 mg
50 mg
Description
Purmorphamine is a smoothened (Smo) receptor agonist (EC50 ∼ 1 μM) and activates the Hedgehog pathway. Purmorphamine induces osteogenesis in mouse mesenchymal progenitor cells (C3H10T1/2). When combined with BMP-4, Purmorphamine can transdifferentiate pre-adipocytes (3T3-L1) and myoblasts (C2C12) into osteoblasts. Purmorphamine induces differentiation of multipotent mesenchymal progenitor cells into osteoblasts, and of spinal motor neurons from pluripotent human stem cells, and protects dopaminergic neurons in a mouse model of Parkinson's disease.
Specifications
Quantity | 10 mg |
Formula Weight | 520.62 |
Chemical Name or Material | Purmorphamine |
Safety and Handling
Recommended Storage | Store at -20°C |
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