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  5. Tocris Bioscience™ Purvalanol B

Tocris Bioscience™ Purvalanol B
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Catalog No. 158110
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50 mg
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15-811-0 10 mg
15-815-0 50 mg
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Catalog No. 15-811-0 Supplier Tocris Bioscience™ Supplier No. 1581/10
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Description

Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

Purvalanol B is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 nM for cdk1 and cdk5, and 6 - 9 nM for cdk2, depending on binding partner). Purvalanol B is selective over a range of other protein kinases (IC50 >10,000 nM). Purvalanol B shows antiproliferative properties, mediated by ERK1 and ERK2. Purvalanol B induces autophagy in cellular models and induces apoptosis in cancer cells, the apoptotic effects can be increased by combining with Rapamycin (Cat. No. 1292).

Chemical Identifiers

CAS 212844-54-7
Molecular Formula C20H25ClN6O3

Specifications

Quantity 10 mg
Formula Weight 432.91
Purity >99%
Molecular Weight (g/mol) 432.909
Chemical Name or Material Purvalanol B

Safety and Handling

Recommended Storage Store at +4°C
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