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Invitrogen™ PXR Polyclonal Antibody
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Catalog No. PIPA5116715
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PIPA5116715 100 μL
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Catalog No. PIPA5116715 Supplier Invitrogen™ Supplier No. PA5116715
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Description

Rabbit Polyclonal Antibody

Positive Samples: Mouse liver, Rat kidney Immunogen sequence: TQPLGVQGLT EEQRMMIREL MDAQMKTFDT TFSHFKNFRL PGVLSSGCEL PESLQAPSRE EAAKWSQVRK DLCSLKVSLQ LRGEDGSVWN YKPPAD.

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PXR
Applications ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2.87 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene NR1I2
Gene Accession No. O54915, O75469, Q9R1A7
Gene Alias BXR; mPXR; Nr1i2; Nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group 1, member 2; nuclear receptor subfamily 1, group I, member 2; ONR 1; ONR1; orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; PAR; PAR 1; PAR 2; PAR q; PAR1; PAR2; PARq; pregnane X nuclear receptor variant 2; Pregnane X receptor; pregnane X receptor (nuclear receptor sub family 1, group I, member 2); PRR; PXR; PXR.1; PXR.2; PXR1; SAR; Steroid and xenobiotic receptor; SXR
Gene Symbols NR1I2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 135-230 of human PXR (NP_0038803).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18171, 84385, 8856
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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