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Invitrogen™ PXR Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5102431
Description
Antibody detects endogenous levels of total NR1I2.
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
Specifications
PXR | |
Polyclonal | |
Unconjugated | |
NR1I2 | |
BXR; mPXR; Nr1i2; Nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group 1, member 2; nuclear receptor subfamily 1, group I, member 2; ONR 1; ONR1; orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; PAR; PAR 1; PAR 2; PAR q; PAR1; PAR2; PARq; pregnane X nuclear receptor variant 2; Pregnane X receptor; pregnane X receptor (nuclear receptor sub family 1, group I, member 2); PRR; PXR; PXR.1; PXR.2; PXR1; SAR; Steroid and xenobiotic receptor; SXR | |
Rabbit | |
Affinity chromatography | |
RUO | |
18171, 84385, 8856 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
O54915, O75469, Q9R1A7 | |
NR1I2 | |
A synthesized peptide derived from human NR1I2(Accession O75469), corresponding to amino acid residues L348-T398. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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