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Invitrogen™ PXR Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5110975
Description
Immunogen sequence: VQGLTEEQRM MIRELMDAQM KTFDTTFSHF KNFRLPGVLS SGCELPESLQ APSREEAAKW SQVRKDLCSL KVSLQLRGED GSVWNYKPPA DSGGKEIFSL LPHMADMSTY MFKGIISFAK VISYFRDLPI EDQISLLK.
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
Specifications
PXR | |
Polyclonal | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
O75469 | |
NR1I2 | |
Recombinant Protein corresonding to Human PXR. Recombinant protein control fragment (Product #RP-105811). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Immunocytochemistry | |
Unconjugated | |
NR1I2 | |
BXR; mPXR; Nr1i2; Nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group 1, member 2; nuclear receptor subfamily 1, group I, member 2; ONR 1; ONR1; orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; PAR; PAR 1; PAR 2; PAR q; PAR1; PAR2; PARq; pregnane X nuclear receptor variant 2; Pregnane X receptor; pregnane X receptor (nuclear receptor sub family 1, group I, member 2); PRR; PXR; PXR.1; PXR.2; PXR1; SAR; Steroid and xenobiotic receptor; SXR | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
8856 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
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