PXR Polyclonal Antibody, Active Motif™

Rabbit Polyclonal Antibody

Supplier:  Active Motif 39590

Catalog No. 50-199-2728

Description

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Specifications

• Antigen: PXR
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NR1I2
• Gene Alias: BXR; mPXR; NR1I2; Nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group 1, member 2; nuclear receptor subfamily 1, group I, member 2; ONR 1; ONR1; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; PAR; PAR 1; PAR 2; PAR q; PAR1; PAR2; PARq; pregnane X nuclear receptor variant 2; Pregnane X receptor; pregnane X receptor (nuclear receptor sub family 1, group I, member 2); PRR; Pxr; PXR.1; PXR.2; PXR1; SAR; Steroid and xenobiotic receptor; SXR
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8856
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: Lot-Specific
• Formulation: 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
• Gene Accession No.: O75469
• Gene Symbols: NR1I2
• Immunogen: This PXR antibody was raised against a peptide containing amino acid residues 57-71 of human PXR.
• Quantity: 10 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG