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Invitrogen™ PYGL Polyclonal Antibody
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Catalog No. PIPA5110248
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PIPA5110248 100 μL
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Catalog No. PIPA5110248 Supplier Invitrogen™ Supplier No. PA5110248
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: IGTMDGANVE MAEEAGEENL FIFGMRIDDV AALDKKGYEA KEYYEALPEL KLVIDQIDNG FFSPKQPDLF KDIINMLFYH DRFKVFADYE AYVKCQDKVS QLYMNPKAWN TMVLKNIAAS GKFSSDRTIK EYAQNIWNVE PSDLKISLSN ESNKVNGN.

This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PYGL
Applications ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.425 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene PYGL
Gene Accession No. P06737, P09811, Q9ET01
Gene Alias glycogen liver; Glycogen phosphorylase, liver form; GPLL; GSD6; Lgp; liver glycogen phosphorylase; phosphorylase, glycogen, liver; PYGL
Gene Symbols PYGL
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 690-847 of human PYGL (NP_0028543).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 110095, 5836, 64035
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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