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Invitrogen™ PYGL Polyclonal Antibody
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Catalog No. PIPA534145
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50 μg
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Catalog No. Quantity
PIPA534145 50 μg
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Catalog No. PIPA534145 Supplier Invitrogen™ Supplier No. PA534145
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Description

Rabbit Polyclonal Antibody

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%).

This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PYGL
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene PYGL
Gene Accession No. P06737
Gene Alias glycogen liver; Glycogen phosphorylase, liver form; GPLL; GSD6; Lgp; liver glycogen phosphorylase; phosphorylase, glycogen, liver; PYGL
Gene Symbols PYGL
Host Species Rabbit
Immunogen Synthetic 17 amino acid peptide from C-terminus of human PYGL.
Purification Method Antigen Affinity Chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5836
Target Species Human, Monkey
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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