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Invitrogen™ PYGO1 Polyclonal Antibody
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Catalog No. PIPA559927
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PIPA559927 100 μL
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Catalog No. PIPA559927 Supplier Invitrogen™ Supplier No. PA559927
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RMPPHVPPRM SSPYCGPYSL RNQPHPFPQN PLGMGFNRPH AFNFGPHDNS SFGNPSYNNA LSQNVNMPNQ HFRQNPAENF SQIPPQNASQ VSNPDLASNF VPGNNSNFTS PLESNHSFIP PPNTFGQAKA PPPKQDFTQG ATK Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 88%.

Pygopus 1 (PYGO1) is a gene located on chromosome 6p21.31, encoding a protein that plays a crucial role in the Wnt signaling pathway, which is fundamental for various developmental processes including cell proliferation, polarity, and fate determination. PYGO1 is a part of the Pygopus family of proteins, characterized by their Plant Homeodomain (PHD) finger domain that facilitates interaction with histones. Within the Wnt signaling pathway, PYGO1 acts as a coactivator by binding to components of the transcription complex, thus aiding in the expression of Wnt target genes. The protein is especially important in embryonic development and is implicated in specific processes such as limb formation and neural development. Dysregulation of PYGO1 and the Wnt pathway is associated with developmental disorders and certain cancers, demonstrating the protein's significance in maintaining cellular homeostasis. Current studies are focusing on the mechanistic aspects of PYGO1's function in transcription regulation and its potential role in therapeutic strategies targeting Wnt signaling-related diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PYGO1
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PYGO1
Gene Accession No. Q9Y3Y4
Gene Alias 2600014C22Rik; PYGO1; pygopus 1; pygopus family PHD finger 1; pygopus homolog 1; pygopus-like protein 1; zgc:172214
Gene Symbols PYGO1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PYGO1. Recombinant protein control fragment (Product #RP-89401).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26108
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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