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Invitrogen™ PYGO1 Polyclonal Antibody
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Catalog No. PIPA5113934
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PIPA5113934 100 μL
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Catalog No. PIPA5113934 Supplier Invitrogen™ Supplier No. PA5113934
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SRSSSTEATN NNPANGTQNK PRQPRGAADA CTTEKSNKSS LHPNRHGHSS For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Cow: 92%; Dog: 100%; Guinea Pig: 79%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 93%.

Pygopus 1 (PYGO1) is a gene located on chromosome 6p21.31, encoding a protein that plays a crucial role in the Wnt signaling pathway, which is fundamental for various developmental processes including cell proliferation, polarity, and fate determination. PYGO1 is a part of the Pygopus family of proteins, characterized by their Plant Homeodomain (PHD) finger domain that facilitates interaction with histones. Within the Wnt signaling pathway, PYGO1 acts as a coactivator by binding to components of the transcription complex, thus aiding in the expression of Wnt target genes. The protein is especially important in embryonic development and is implicated in specific processes such as limb formation and neural development. Dysregulation of PYGO1 and the Wnt pathway is associated with developmental disorders and certain cancers, demonstrating the protein's significance in maintaining cellular homeostasis. Current studies are focusing on the mechanistic aspects of PYGO1's function in transcription regulation and its potential role in therapeutic strategies targeting Wnt signaling-related diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PYGO1
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene PYGO1
Gene Accession No. Q9Y3Y4
Gene Alias 2600014C22Rik; PYGO1; pygopus 1; pygopus family PHD finger 1; pygopus homolog 1; pygopus-like protein 1; zgc:172214
Gene Symbols PYGO1
Host Species Rabbit
Immunogen Synthetic peptide directed towards the middle region of human PYGO1.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26108
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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