Invitrogen™ PYGO2 Monoclonal Antibody (539730)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524240

Catalog No. PIMA524240

Description

In direct ELISAs, no cross-reactivity with recombinant human Pygopus-1 or recombinant mouse Pygopus-1 is observed. Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

The PYGO2 gene encodes pygopus family PHD finger 2, a key component of the Wnt signaling pathway, which is critical for embryonic development, cell proliferation, and differentiation. PYGO2 operates as a chromatin remodeling factor, interacting with the beta-catenin-LEF/TCF transcriptional complex, facilitating the transcription of Wnt target genes by recruiting chromatin-modifying enzymes. This activity is vital for maintaining the balance between stem cell renewal and differentiation in various tissues, including the brain and the skin. Additionally, PYGO2 plays significant roles in spermatogenesis and hematopoiesis by modulating gene expression necessary for these processes. Dysregulation of PYGO2 expression can lead to developmental abnormalities and is often implicated in cancer progression, indicating its potential as a biomarker for tumorigenic stem cell-like properties and metastatic behavior. Research continues to explore PYGO2's mechanisms and interactions to understand its contributions to development and its implications in disease states, particularly in cancer biology.

Specifications

• Antigen: PYGO2
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q9BRQ0
• Gene Symbols: PYGO2
• Immunogen: E. coli-derived recombinant human Pygopus-2 Met160-Glu336.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 539730
• Conjugate: Unconjugated
• Gene: PYGO2
• Gene Alias: 1190004M21Rik; mpygo2; PP7910; PYGO2; pygopus 2; pygopus family PHD finger 2; pygopus homolog 2; RGD1308535
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 90780
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized