Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIMA524240

Invitrogen™ PYGO2 Monoclonal Antibody (539730)
GREENER_CHOICE

Catalog No. PIMA524240
Change view
Click to view available options
Quantity:
100 μg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIMA524240 100 μg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIMA524240 Supplier Invitrogen™ Supplier No. MA524240
Add to Cart
Add to Cart

Description

Mouse Monoclonal Antibody

In direct ELISAs, no cross-reactivity with recombinant human Pygopus-1 or recombinant mouse Pygopus-1 is observed. Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

The PYGO2 gene encodes pygopus family PHD finger 2, a key component of the Wnt signaling pathway, which is critical for embryonic development, cell proliferation, and differentiation. PYGO2 operates as a chromatin remodeling factor, interacting with the beta-catenin-LEF/TCF transcriptional complex, facilitating the transcription of Wnt target genes by recruiting chromatin-modifying enzymes. This activity is vital for maintaining the balance between stem cell renewal and differentiation in various tissues, including the brain and the skin. Additionally, PYGO2 plays significant roles in spermatogenesis and hematopoiesis by modulating gene expression necessary for these processes. Dysregulation of PYGO2 expression can lead to developmental abnormalities and is often implicated in cancer progression, indicating its potential as a biomarker for tumorigenic stem cell-like properties and metastatic behavior. Research continues to explore PYGO2's mechanisms and interactions to understand its contributions to development and its implications in disease states, particularly in cancer biology.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PYGO2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 539730
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene PYGO2
Gene Accession No. Q9BRQ0
Gene Alias 1190004M21Rik; mpygo2; PP7910; PYGO2; pygopus 2; pygopus family PHD finger 2; pygopus homolog 2; RGD1308535
Gene Symbols PYGO2
Host Species Mouse
Immunogen E. coli-derived recombinant human Pygopus-2 Met160-Glu336.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 90780
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2b
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.