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Invitrogen™ PYGO2 Polyclonal Antibody
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Catalog No. PIPA582841
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100 μL
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PIPA582841 100 μL
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Catalog No. PIPA582841 Supplier Invitrogen™ Supplier No. PA582841
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SLSQRFAQPG APFGPSPLQR PGQGLPSLPP NTSPFPGPDP GFPGPGGEDG GKPLNPPAST AFPQEPHSGS PAAAVNGNQP SFPPNSSGRG GGTPDANSLA PPGKAGGGSG PQPPPGLVYP CGA Highest antigen sequence indentity to the following orthologs: Mouse - 95%, Rat - 95%.

The PYGO2 gene encodes pygopus family PHD finger 2, a key component of the Wnt signaling pathway, which is critical for embryonic development, cell proliferation, and differentiation. PYGO2 operates as a chromatin remodeling factor, interacting with the beta-catenin-LEF/TCF transcriptional complex, facilitating the transcription of Wnt target genes by recruiting chromatin-modifying enzymes. This activity is vital for maintaining the balance between stem cell renewal and differentiation in various tissues, including the brain and the skin. Additionally, PYGO2 plays significant roles in spermatogenesis and hematopoiesis by modulating gene expression necessary for these processes. Dysregulation of PYGO2 expression can lead to developmental abnormalities and is often implicated in cancer progression, indicating its potential as a biomarker for tumorigenic stem cell-like properties and metastatic behavior. Research continues to explore PYGO2's mechanisms and interactions to understand its contributions to development and its implications in disease states, particularly in cancer biology.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PYGO2
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PYGO2
Gene Accession No. Q9BRQ0
Gene Alias 1190004M21Rik; mpygo2; PP7910; PYGO2; pygopus 2; pygopus family PHD finger 2; pygopus homolog 2; RGD1308535
Gene Symbols PYGO2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PYGO2. Recombinant protein control fragment (Product #RP-89384).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 90780
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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