Invitrogen™ PYGO2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531553

Catalog No. PIPA531553

Description

Recommended positive controls: NIH-3T3. Predicted reactivity: Human (96%), Mouse (100%), Rat (99%), Pig (97%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The PYGO2 gene encodes pygopus family PHD finger 2, a key component of the Wnt signaling pathway, which is critical for embryonic development, cell proliferation, and differentiation. PYGO2 operates as a chromatin remodeling factor, interacting with the beta-catenin-LEF/TCF transcriptional complex, facilitating the transcription of Wnt target genes by recruiting chromatin-modifying enzymes. This activity is vital for maintaining the balance between stem cell renewal and differentiation in various tissues, including the brain and the skin. Additionally, PYGO2 plays significant roles in spermatogenesis and hematopoiesis by modulating gene expression necessary for these processes. Dysregulation of PYGO2 expression can lead to developmental abnormalities and is often implicated in cancer progression, indicating its potential as a biomarker for tumorigenic stem cell-like properties and metastatic behavior. Research continues to explore PYGO2's mechanisms and interactions to understand its contributions to development and its implications in disease states, particularly in cancer biology.

Specifications

• Antigen: PYGO2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PYGO2
• Gene Alias: 1190004M21Rik; mpygo2; PP7910; PYGO2; pygopus 2; pygopus family PHD finger 2; pygopus homolog 2; RGD1308535
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 295251, 68911, 90780
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ChIP Assay, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 0.65 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q9BRQ0
• Gene Symbols: PYGO2
• Immunogen: Full length mouse Pygopus 2 Recombinant protein.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG