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Invitrogen™ PYK2 Monoclonal Antibody (5E2D5)
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Catalog No. PIMA515407
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100 μL
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PIMA515407 100 μL
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Catalog No. PIMA515407 Supplier Invitrogen™ Supplier No. MA515407
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Description

Mouse Monoclonal Antibody

MA5-15407 targets PYK2 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples. The MA5-15407 immunogen is purified recombinant fragment of PYK2 (aa815-997) expressed in E. Coli.. MA5-15407 detects PYK2 which has a predicted molecular weight of approximately 115.8kDa.

PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling. FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress. Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PYK2
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 5E2D5
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation ascites with 0.03% sodium azide
Gene PTK2B
Gene Accession No. Q14289
Gene Alias CADTK; CAK beta; CAKB; CAKbeta; CAK-beta; calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; cellular adhesion kinase beta; E430023O05Rik; FADK; FADK 2; FADK2; FAK; FAK1; FAK2; focal adhesion kinase 2; FRNK; PKB; pp125FAK; proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; PTK; PTK2 protein tyrosine kinase 2 beta; PTK2B; PTK2B protein tyrosine kinase 2 beta; PYK2; RAFTK; related adhesion focal tyrosine kinase
Gene Symbols PTK2B
Host Species Mouse
Immunogen Purified recombinant fragment of PYK2 (aa815-997) expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2185
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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