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Invitrogen™ PYK2 Recombinant Rabbit Monoclonal Antibody (SC06-15)
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Catalog No. PIMA542439
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PIMA542439 100 μL
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Catalog No. PIMA542439 Supplier Invitrogen™ Supplier No. MA542439
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Control: Mouse brain tissue lysates, Hela, SHG-44, SH-SY5Y, human tonsil tissue, human spleen tissue, human kidney tissue, mouse brain tissue, mouse kidney tissue. Subcellular Location: Cell membrane, Nucleus, Cytoplasm, perinuclear region, focal adhesion, lamellipodium, cell cortex.

PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling. FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress. Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PYK2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone SC06-15
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 40% glycerol, 0.05% BSA and 0.05% sodium azide; pH 7.4
Gene PTK2B
Gene Accession No. P70600, Q14289, Q9QVP9
Gene Alias CADTK; CAK beta; CAKB; CAKbeta; CAK-beta; calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; cellular adhesion kinase beta; E430023O05Rik; FADK; FADK 2; FADK2; FAK; FAK1; FAK2; focal adhesion kinase 2; FRNK; PKB; pp125FAK; proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; PTK; PTK2 protein tyrosine kinase 2 beta; PTK2B; PTK2B protein tyrosine kinase 2 beta; PYK2; RAFTK; related adhesion focal tyrosine kinase
Gene Symbols PTK2B
Host Species Rabbit
Immunogen Synthetic peptide within N-terminal human PYK2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19229, 2185, 50646
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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