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  5. Tocris Bioscience™ Pyr 10

Tocris Bioscience™ Pyr 10
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Catalog No. 694150
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50 mg
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Catalog No. Quantity
69-415-0 50 mg
69-411-0 10 mg
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Catalog No. 69-415-0 Supplier Tocris Bioscience™ Supplier No. 6941/50
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Description

Selective TRPC3 inhibitor

Pyr 10 is a TRPC3 (transient receptor potential canonical 3) channel inhibitor (IC50 = 0.72 μM for TRPC3 mediated calcium entry in vitro), which displays approximately 18-fold selectivity for TRPC3-mediated receptor operated calcium entry (ROCE) over STIM1/Orai1-mediated store operated calcium entry (SOCE). Pyr 10 inhibits NFATc3 activation and inhibits proliferation of rat ventricular cardiac fibroblasts.

Specifications

Chemical Name or Material N-[4-[3,5-bis(Trifluoromethyl)-1 H-pyrazol-1-yl]phenyl]-4-methylbenzenesulfonamide
CAS 1315323-00-2
Quantity 50 mg
Target TRPC Channel Blockers
Molecular Formula C18H13F6N3O2S
Purity 0.98
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