Tocris Bioscience Pyridostatin pentahydrochloride
Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest
Manufacturer: Tocris Bioscience 4763/10
DescriptionBinds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (Kd = 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).
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