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Tocris Bioscience™ Pyridostatin pentahydrochloride

Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest

Manufacturer:  Tocris Bioscience™ 4763/50

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Catalog No. 47-635-0


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Description

Description

Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (Kd = 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).
Specifications

Specifications

1781882-65-2
Pyridostatin pentahydrochloride
778.94
Pyridostatin pentahydrochloride
>98
50mg
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