Invitrogen™ Pyruvate Carboxylase Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120984

Catalog No. PIPA5120984

Description

Positive test controls include: HepG2, HeLa, MCF7, A-549, U-251MG, Mouse liver, Mouse brain, Rat liver, Rat brain. The target is usually found in the following locations: Mitochondrion matrix. Immunogen sequence: HSMGLGSKFK EVKKAYVEAN QMLGDLIKVT PSSKIVGDLA QFMVQNGLSR AEAEAQAEEL SFPRSVVEFL QGYIGVPHGG FPEPFRSKVL KDLPRVEGRP GASLPPLDLQ ALEKELVDRH GEEVTPEDVL SAAMYPDVFA HFKDFTATFG PLDSLNTRLF LQGPKIAEEF EVELERGKTL HIKALAVSDL NRAGQRQVFF ELNGQLRSIL VKDTQAMKEM HFHPKALKDV KGQIGAPMPG KVIDIKVVAG AKVAKGQPLC VLSAMKMETV VTSPMEGTVR KVHVTKDMTL EGDDLILEIE.

Pyruvate Carboxylase requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency.

Specifications

• Antigen: Pyruvate Carboxylase
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PC
• Gene Alias: EC 6.4.1.1; Pc; Pcb; Pcx; PYC; pyruvate carboxylase; pyruvate carboxylase, mitochondrial; pyruvate decarboxylase; pyruvic carboxylase
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18517, 18563, 25104, 5091
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 1.96 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P11498, P52873, Q05920
• Gene Symbols: PC, Pcx
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 879-1178 of human Pyruvate carboxylase (Pyruvate carboxylase (PC)) (NP_0010358061).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG